Description
Domperidone is a dopamine antagonist. It acts on the gut and on the part of the brain that triggers vomiting, and in the UK its licence is restricted to the relief of nausea and vomiting. It is prescribed at the lowest effective dose for the shortest time, and courses are usually short. Tablets are taken before meals; taken after food, they are absorbed more slowly.
Domperidone can affect the electrical rhythm of the heart, so it is not suitable if you have a heart conduction problem, a low blood potassium or magnesium level, or moderate to severe liver disease, and it should not be combined with medicines that prolong the QT interval or with strong inhibitors of the liver enzyme CYP3A4 such as ketoconazole and erythromycin.
Tell your prescriber about every other medicine you take. Seek medical advice if you develop palpitations or fainting.
- Dopamine antagonist antiemetic, 10mg tablets
- UK licence restricted to the relief of nausea and vomiting
- Taken before meals, at the lowest dose for the shortest time
- Not suitable with heart conduction or rhythm problems
- Interacts with QT-prolonging medicines and CYP3A4 inhibitors
- Seek medical advice about palpitations or fainting
